Lecturer:
Jeff Gladd, MD, CHAIRMAN Susan Blum, MD Tom O'Bryan, DC Shayma Kazmi, MD, RPh Mark Tager, MD James Maskell Derrick DeSilva, Jr, MD Jacques Simon, Esq Sarath Malepati, MD Ron Hoffman, MD Joel Evans, MD Anita Teresa Boeninger, RYT Melissa Crispell Joseph Hickey, MD Mette Dyhrberg Thomas Blomseth Christiansen Lillie Rosenthal, DO Mark Menolascino, MD Georgia Tetlow, MD Aimon Kopera, MD & Peter Evans, PhD
Lecturer:
Erik Goldman Jeff Gladd, MD Shilpa Saxena, MD Michael Gaeta, Lac Chad Larson, NMD, DC Steven Masley, MD David Perlmutter, MD Marcela Dominguez, MD Erin Martin, DO Richard Jaffe, Esq. Deanna Minich, PhD Harry Massey Miriam Zacharias James Maskell John La Puma, MD Tina Beaudoin, ND Mette Dyhrberg & Thomas Blomseth Christiansen
Predictive antibody testing puts state of the art immunologic tools in the hands of practicing clinicians, enabling early detection of triggers & predisposing factors for many disorders---long before they become chronic and debilitating!
In this online course, you'll earn 6 AMA Category 1 credits as you learn how predictive antibody testing can revolutionize your care for patients with:
Gastrointesteinal + Liver
Thyroid, Adrenal, Reproductive Organs
Cardiovascular Disease
Diabetes
Bone and Joint Disorders
Neurocognitive Problems
Faculty: Aristo Vojdani, PhD; Thomas Alexander, MD; Chad Larson, DC, NMD
Predictive Antibodies: Clinical Applications for Early Detection of Autoimmunity
This online CME activity is sponsored by Holistic Education Exchange and the Institute for Medical Studies, and is supported by an educational grant from Cyrex Laboratories. Earn up to 6 AMA PRA Category 1 Credits™
Release Date: September 1, 2013 Expiration Date: August 31, 2015
Autoimmune disorders affect roughly 53 million Americans, and many more worldwide. In the vast majority of cases, these conditions go improperly diagnosed for years, causing untold suffering.
Recent advances in immunology could change this scenario, enabling clinicians to detect many of these diseases years before they become debilitating, at stages when they are most responsive to lifestyle-based interventions.
This, combined with a better understanding of the interaction between gut permeability, food & environmental allergens, and genetic predispositions have the potential to greatly improve the care of people at risk for autoimmune disorders.
In this 6-part course, you’ll learn the fundamental processes underlying autoimmune reactions; the ways in which these reactions manifest in diverse organ systems; the role of food allergens and environmental triggers in the autoimmune process; the relevance of autoantibodies as biomarkers, and the clinical application of predictive autoantibody testing in patient care.
Course CME Instructions
In order to receive ACCME accreditation, you must complete the course material, correctly answer questions in the quiz, and complete the post-test evaluation. You will then be able to print a CME certificate to retain for your records.
This course must be purchased in its entirety; lectures can NOT be purchased individually.
Predictive Antibodies
Course: Predictive Antibodies: Clinical Applications for Early Detection of Autoimmunity
Faculty and Disclosures
Course Details
Lecture 1: Predictive Antibodies
Lecture 2: Gastrointestinal and Liver
Lecture 3: Thyroid, Adrenal, Reproductive Organs
Lecture 4: Cardiovascular and Diabetes
Lecture 5: Bone and Joint
Lecture 6: Neurological
Course: Predictive Antibodies: Clinical Applications for Early Detection of Autoimmunity
Faculty and Disclosures
Course Faculty
Aristo Vojdani, PhD, MSc, CLS Credentials • PhD in Immunology and Microbiology from Bar Ilan University, Israel • 45 years of research in immunology • Over 135 peer-reviewed scientific journal publications • 14 US patents for laboratory assessments
Thomas Alexander, MD Credentials • University of Missouri-Kansas City School of Medicine • Board Certified Internal Medicine • 14 years clinical practice • Hospitalist – Scottsdale Shea Hospital, Scottsdale, AZ
Chad Larson, DC Credentials • Southern California University of Health Sciences (Los Angeles College of Chiropractic) • 14 years of chiropractic care • Certified Clinical Nutritionist • Certified Strength and Conditioning Specialist
Financial Disclosure Statement(s)
In accordance with CME guidelines, any faculty or planner conflicts of interest (COI) related to this CME activity are listed below and have been resolved through the oversight of the CME provider. Both program design and content have been reviewed to ensure fair balance and avoidance of any commercial bias.
• Aristo Vojdani, PhD, Presenter –Chief Scientific Advisor, Cyrex Laboratories • Thomas Alexander, MD, Presenter –Director of Clinical Support Services, Cyrex Laboratories • Chad Larson, DC, Presenter –Clinical Consultant, Cyrex Laboratories • Stanley Golanty, MD, CME Reviewer –No conflicts of interest • Meg Sinclair, CME Activity Planner –No conflicts of interest
Requirements
This online CME activity is sponsored by Holistic Education Exchange and the Institute for Medical Studies, and is supported by an educational grant from Cyrex Laboratories. Earn up to 6 AMA PRA Category 1 Credits™.
Learning Objectives
Discuss the appropriate use of predictive autoantibodies.
Understand how environmental factors are initiators, first of antibody production, then of autoimmunities.
Detect the extra-intestinal autoimmunities associated with Celiac disease and non-Celiac gluten sensitivity.
Understand the concept of cross-reactivity between food antigens and human tissues.
Identify patients who are at risk for developing environmentally-induced autoimmune disorders.
Review the use of biomarkers in autoimmune gastrointestinal and liver disorders.
Identify non-traditional manifestations of autoimmune disorders.
Review the use of biomarkers in endocrine, reproductive, neurological and cardiovascular system disorders.
Review current concepts in multiple autoimmune syndrome.
Discuss the relationships between GI disorders and extra-intestinal autoimmunities.
Identify the linkage between intestinal permeability and bone and joint disorders.
Review the use of biomarkers in neurological disorders.
Identify current concepts of intestinal and blood-brain permeability.
Discuss the appropriate use of biomarkers to monitor treatment protocols for a wide range of autoimmune diseases.
Target Audience
This online continuing education activity is intended for Medical doctors, Osteopaths, Advance Practice Nurses, Chiropractors, Physician Assistants, Naturopaths, and other healthcare professionals involved in the care of patients at risk for chronic autoimmune disorders.
ACCREDITATION
This CME activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the Joint Sponsorship of the Institute for Medical Studies (IMS) and Holistic Primary Care. The Institute for Medical Studies is accredited by the ACCME to provide continuing medical education for physicians.
IMS designates this enduring material for a maximum of six AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Non-Physicians may claim credits for activities approved for AMA PRA Category 1 Credits™. in most states. Please check with your local board for recertification.
1) In order to receive ACCME accreditation, you must complete the course material, correctly answer questions in the quiz, and complete the post-test evaluation. You will then be able to print a CME certificate to retain for your records
To view the HD video stream (no downloads) you will need high-speed internet access (DSL or cable broadband), and a standard browser that supports Flash and HTML5. This website is optimized to be viewed with Chrome or Firefox. If you experience any problems while using another web browser please, please consider using one of the recommended browsers before contacting us for support. If these steps do not resolve your issues (or you want to send us feedback), please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it., or fill out our feedback form by clicking on <a href="https://www.holisticeducationexchange.net/index.php/tell-us-what-you-think">Tell us what you think</a> in the top menu. Users on mobile devices should be aware that streaming over a cellular data network (instead of wi-fi) will use significant bandwith (hundreds of Megabytes per hour of video). Low bandwidth users may wish stream or download the audio only versions of our lectures.
Lecture 1: Predictive Antibodies
Aristo Vojdani, PhD
Autoimmune disorders affect roughly 53 million people in the US and many more worldwide. A growing body of research shows that autoantibodies –antibodies that target one’s own tissues--appear in the blood years before disease becomes manifest. Why does the human body react to its own antigens? The causes may be traced to bacterial or viral infections, exposure to haptenic toxins and xenobiotics, physical and mental stressors, and sensitivities to certain allergenic dietary proteins. Early detection of autoantibodies can facilitate effective lifestyle-based interventions, sometimes years before serious symptoms emerge. In this lecture, you’ll learn the basic mechanisms of autoantibody production, the stages of autoimmunity, the role of autoimmunity in common chronic disorders, and the clinical application of predictive antibody testing.
Learning Objectives
Discuss the appropriate use of predictive autoantibodies.
Understand how environmental factors are initiators, first of antibody production, then of autoimmunities.
Detect the extra-intestinal autoimmunities associated with Celiac disease and non-Celiac gluten sensitivity.
Understand the concept of cross-reactivity between food antigens and human tissues.
Identify patients who are at risk for developing environmentally-induced autoimmune disorders.
Lecture 2: Gastrointestinal and Liver
Thomas Alexander, MD
Increased intestinal permeability plays a significant role in the pathogenesis of environmentally-induced autoimmune disorders, by providing an opening for trigger antigens to invade the body. Hippocrates stated, “All disease begins in the gut,” a statement that reflects a deep understanding of the importance of intestinal barrier integrity, and one that modern research and clinical experience is validating. Often, the target of the autoimmunity is the gut itself. Celiac disease—one of the most common autoimmune conditions--is associated with multiple extra-intestinal autoimmunities. Autoimmune liver disease is less common, but is one of the manifestations of Celiac disease. In this lecture, you’ll learn about predictive antibodies for Celiac disease, autoimmune liver disorders, and other autoimmune conditions, as well as how to use autoantibody testing in the differential diagnosis of these disorders.
Learning Objectives
Discuss the appropriate use of predictive autoantibodies.
Review the use of biomarkers in autoimmune gastrointestinal and liver disorders.
Identify non-traditional manifestations of autoimmune disorders.
Discuss the appropriate use of biomarkers to monitor treatment protocol.
Lecture 3: Thyroid, Adrenal, Reproductive Organs
Chad Larson, DC
There is a strong inter-relationship between the immune system and the endocrine system. Autoimmune reactions can have far-reaching negative effects on the endocrine and reproductive glands. Particularly vulnerable are the thyroid, the adrenals and the gonads. For example, Celiac disease—one of the most common autoimmune conditions—can result in infertility secondary to reproductive organ autoimmune reactivity in both men and women. Predictive antibody testing enables clinicians to detect important changes well before significant tissue damage occurs and patients experience metabolic changes. In this lecture, you’ll learn: how autoimmune reactions affect the thyroid, adrenals, ovaries, and testes; how multiple autoimmune processes fit together in what is called the Autoimmune Polyendocrine Syndrome (APS); and how food antigens and pathogens like Candida trigger these reactions.
Learning Objectives
Discuss the appropriate use of predictive autoantibodies.
Review the use of biomarkers in thyroid, adrenal and reproductive organ disorders.
Review current concepts in multiple autoimmune syndrome.
Discuss the appropriate use of biomarkers to monitor treatment protocol.
Lecture 4: Cardiovascular and Diabetes
Thomas Alexander, MD
Autoimmune mechanisms play a key role in several cardiovascular diseases, including heart failure, dilated cardiomyopathy, atherosclerosis, Chagas' disease, myocarditis and rheumatic fever. Type 1 diabetes has long been recognized as an autoimmune disorder, and researchers are now debating the role of autoimmunity in type 2 diabetes. Clearly diabetes and cardiovascular disease are inter-related, and many people with these conditions also have other autoimmune disorders. By identifying and addressing the autoimmune components of these diseases, clinicians have the possibility of greatly improving patient outcomes. In this lecture, you’ll learn about specific autoantibodies associated with CVD and diabetes, as well as the connection between CVD, autoantibodies, and seemingly “unrelated” disorders like Celiac disease.
Learning Objectives
Discuss the appropriate use of predictive autoantibodies.
Review the use of biomarkers in cardiovascular disease and diabetes.
Discuss the relationships between GI disorders and extra-intestinal autoimmunities.
Discuss the appropriate use of biomarkers to monitor treatment protocol.
Lecture 5: Bone and Joint
Chad Larson, DC
Autoimmune reactions play a central role in the pathogenesis and progression of three common musculoskeletal conditions: osteoarthritis, rheumatoid arthritis, and osteoporosis. Hormones, nutritional status, exercise and use of certain medication may also play a role in these diseases. Interestingly, musculoskeletal disorders are often linked to increased intestinal barrier permeability, including Celiac disease. In this lecture, you’ll learn how autoimmune reactions factor into the pathogenesis of osteoporosis, osteoarthritis, and rheumatoid arthritis; how specific predictive autoantibodies can be used for earlier diagnosis; how these musculoskeletal conditions are related to GI problems like Celiac; and how to utilize this information to improve patient care.
Learning Objectives
Discuss the appropriate use of predictive autoantibodies.
Review the use of biomarkers in bone and joint disorders.
Identify the linkage between intestinal permeability and bone and joint disorders.
Discuss the appropriate use of biomarkers to monitor treatment protocol.
Lecture 6: Neurological
Aristo Vojdani, PhD
Since time immemorial, man has tried to understand how his gut and his brain are connected. Bidirectional signaling between the brain and gut, and many points in between, has been confirmed by numerous studies. The gut’s influence on the brain cannot be overestimated. Studies have linked GI diseases to neurological disorders such as depression, anxiety, multiple sclerosis and autism. In this lecture, you’ll learn about autoantibodies predictive of neurological disorders; the role of gliadin peptide cross-reactivity in neurological conditions; and the ways in which Celiac disease and other GI conditions manifest as neurocognitive problems. Application of autoantibody testing opens the possibility of prevention, amelioration and even reversal of autoimmune disorders, both gastrointestinal and neurodegenerative, through treatment modalities involving the repair of the gut and brain barriers.
Learning Objectives
Discuss the appropriate use of predictive autoantibodies.
Review the use of biomarkers in neurological disorders.
Identify current concepts of intestinal and blood-brain permeability.
Discuss the appropriate use of biomarkers to monitor treatment protocol.